One Compartment Model

This simulation describes the relationships between patient plasma Concentrations and pharmacokinetic parameter estimates for a drug with one compartment model distribution and first order elimination characteristics after IV bolus administration. Specifically, this simulation demonstrates how changes in a patient's volume of distribution and/or clearance will alter the patient's plasma concentration of the drug over time.

Two Compartment Model

This simulation describes the relationships between patient plasma concentrations and pharmacokinetic parameter estimates for a drug with two compartment model distribution and first order elimination characteristics. Specifically, this simulation demonstrates how changes in the microrate constants (K10, K12, and K21) will alter the patients plasma concentration of the drug over time.

Infusion Model

This simulation describes the relationship between volume of distribution and clearance in relation to a patients plasma concentration versus time profile upon continuous intravenous infusion of a drug with one compartmental model distribution and first order elimination. This animation also describes a patients profile after stopping the infusion and during the addition of an IV bolus loading dose.

Extravascular Model

This simulation describes the relationships between patient plasma concentrations and pharmacokinetic parameter estimates for a drug with one compartment model distribution and first order elimination characteristics after extravascular administration. Specifically, this simulation demonstrates how changes in a patient's PK parameters will alter the patient's plasma concentration of the drug over time.